Methods

Measuring the 1D spectrum of different nuclei with a wide range of frequencies such as 1H, 13C, 15N, 19F, 31P, 11B, 183W, etc. 

To increase sensitivity and to improve spectral resolution 1H decoupling can be added (zgpg, zgig). 

In 1H spectra, solvent suppression can be…

Homonuclear interactions such as 1H-1H can be measured by different experiments:  

• COSY or TOCSY can show correlations through bond and NOESY or ROESY can reveal correlations through space. 
• Heteronuclear (1H-13C, 1H-31P, 1H-15N) through-bond correlation can be measured by…

Relaxation in NMR is the process by which an excited magnetic state returns to equilibrium. After excitation of the magnetization by a radio frequency (RF) pulse it relaxes back to equilibrium by two different mechanisms. First there is a coherence loss of the magnetization in…

Diffusion NMR or Diffusion Ordered SpectroscopY (DOSY) is measured by combining radiofrequency (RF) pulses with pulsed field gradients. 

The simplest sequence to measure diffusion NMR is called the pulsed field gradient spin-echo (PGSE). The magnetization is excited with a 90…

Chemical Exchange Saturation Transfer or CEST is an experiment that allows the indirect detection of low concentrated species with the sensitivity of the pool at high concentration. One application of this technique is to study dynamics in host-guest system, which is termed GEST…